Authors: Tymchenko O.I., Koba O.P., Mykytenko D.O., Maksiyan O.I., Lynchak O.V.
Introduction. In conditions of decreasing birthrate, the infertile couples as well as couples with reproductive losses could be as a reserve of increasing birthrate. These families want, but cannot have got their own children. A sequential detection and study of complex cases and mechanisms of infertility development allows us to determine the exact individual strategy of treatment. In the same time, the measures of primary prevention (based on the prevention of negative influence of different risk factors) are efficient on a population level. Even in a case of reproductive clinics activity, the prevention measures on a primary stage of pregnancy planning are necessary and urgent. Many factors, which could be important in human pathology development, should be taken into account in order to prognostication of individual reproductive health status. That is why process of regional investigation results extrapolation to the other regions without analysis of their features is inadequate and ineffective.
The aim is to determine the infertility development risk factors prevalence between people of the Chernivetsky region over time.
Material and Methods. The primary materials were 273 special registration cards for cases of infertile couples in the Chernivetsky region (in 1999–2003 and 2012–2013).The cases of healthy children birth were taken as control (1010). The risk was calculated as Odds Ratio indicator, including 95 % confidence interval. The infertility risk factors prevalence was determined by comparison of infertile couples percentage in 1999–2003 and 2012–2013. The critical level of statistical criterions was accepted as P ≤ 0.05.
Discussion. In 1999–2003 the main infertility risk factors were chronic female and male infections (OR = 4.02 95%CI:3.35–4.82 and 4.82 95%CI:4.18–5.61 accordingly). In comparison with 1999–2003 / 2012–2013, we noticed the absence of differences in prevalence of extragenital and endocrine pathology, chronic infections, professional risks as well as smoking between infertile couples. Over time between infertile women and men, we detected increasing of educational level and fraction of unemployed individuals. Moreover, 7-time increasing of fraction of couples, who used paid medical services, was shown as well as 4-time increasing of fraction of couples, whose total income allows them to use paid medical services.
Key words: infertility, married couples, risk factors.