The aim of the present study was to establish clinical, diagnostic and predicted significance of beta-2-microglobulinuria as a marker of renal damage at essential hypertension and to determine the prevalence of increased urinary beta-2-microglobulin excretion in essential hypertension. The level of beta-2-microglobulinuria was measured in a group of 46 patients with essential hypertension (21 women, 25 men) and in 17 healthy subjects (as control group). Subjects with clinically significant accompanying pathology were carefully excluded during the patient’s selection. The urinary albumin and beta-2-microglobulin excretion were determined by immune-enzyme assay. According to protocol of the study, all patients have undergone examination: clinical, laboratory and instrumental studies, including echocardiography, 24-h ambulatory blood pressure monitoring, investigation of renal hemodynamic by ultrasound Doppler and evaluation renal functional reserve, estimate of glomerular filtration rate according to Cockroft-Gault formula. The beta-2-microglobulinuria value in hypertensive patients was statistically increase from that observed in normal controls. All patients with essential hypertension were distributed into two groups: with normal value (<400 µg/l) and hyperbeta-2-microglobulinuria. In the second group were registered significantly more often violation of intrarenal hemodynamic, left ventricular hypertrophy, proteinuria, decrease of glomerular filtration rate. The method of beta-2-microglobulin evaluation has enough high specificity, sensitivity in diagnostic hypertensive nephropathy. We conclude that the increased urinary beta-2-microglobulin excretion in patients with essential hypertension is a significant marker of the hypertensive nephropathy.
Keywords: beta-2-microglobulinuria, renal reserve, hypertension, myocardial remodeling, microalbuminuria.
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