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MAIN INDICES OF BLOOD-BRAIN BARRIER DAMAGE AT ACUTE PHASE OF ISCHEMIC STROKE

Authors: Volodymyr Lychko, Volodymyr Malakhov

Pages: 425-429

Abstract


Introduction: An acute ischemic stroke causes expressed disruption of blood-brain barrier (BBB), which significantly affects prognosis. One of the indicators of the effect is the level of albumin in the cerebrospinal fluid (CSF).

The purpose of the study was to examine the level of albumin in the CSF in patients with ischemic stroke and to assess the role one as index of BBB dysfunction. In the study were involved 121 patients who had first incident of brain infarction (mean age was 64.4 ± 0.9 years) were comprehensively examined and the concentration of albumin in serum and CSF were determined.

The results of the study show level of albumin in CSF was clearly elevated in patients with increased severity of infarction. Under treatment, there was a general trend of increase in level of CSF albumin in patients of all groups, remarkably in those with severe condition.

Conclusion: The onset of brain infarction is characterize by significant functional changes of the BBB confirmed by a sharp increase in the level of CSF albumin (34.6 %) which directly correlated with the severity of patients. Dynamics of treatment have shown unfavorable prognostic signs due to increase in levels of albumin by 1.7 times observed in patients with severe condition.

Key words: albumin, cerebrospinal fluid, barrier, stroke, prognosis, dysfunction.

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