Authors: Maidannyk Vitaliy, Burlaka Ievgeniia
Introduction. Diabetic nephropathy is the leading cause of death in patients with diabetes mellitus (DM). Two key mechanisms are involved in the development of diabetic nephropathy – advanced glycation and oxidative stress. Formation of diabetic nephropathy depends on the degree control of the diabetes, which is an indicator of the level of glycosylated hemoglobin (HbA1c).
Purpose: To investigate the level of metabolic disorders in children with DM type I and diabetic nephropathy.
Material and methods. The study involves 18 children with DM type I and diabetic nephropathy (aged 10 to 16 years). The affinity of hemoglobin to oxygen and lipid oxidation ratio were determined using spectrophotometric method.
Results. In the group of children with newly diagnosed DM type I a high rate of affinity of hemoglobin to oxygen as compared to the control group has been recorded. In the group of children with DM type I and developed diabetic nephropathy the level of the marker is significantly lower as compared to control group. Stage-dependent increase of the level of lipids oxidation coefficient depending on the efficacy of control of DM has been documented.
Discussion. We examined two components of pathogenesis and indicators of the persistent influence of glucose in diabetes mellitus – outcomes of the formation of advanced glycation products (HbA1c) and lipids oxidation coefficient. Further investigations of the advanced glycation products formation intermediates in secondary activation cascade of reactions, including the pathogenesis of progression of diabetic nephropathy is a promising direction to create schemes of prevention and treatment of diabetic kidney disease.
Keywords: diabetes mellitus type I, diabetic nephropathy, metabolic disorders