Get Adobe Flash player

LEFT VENTRICLE DIASTOLIC DYSFUNCTION IN POSTMENOPAUSAL WOMEN WITH ESSENTIAL ARTERIAL HYPERTENSION

Authors: Malynovska O.Ya.

Pages: 453-460

Abstract


Purpose: To determine the characteristics of diastolic dysfunction of the left ventricular myocardium in women with arterial hypertension and menopausal syndrome, depending on the severity of menopause.

Materials and methods. The study enrolled 120 women suffering from hypertension, postmenopausal from 1 to 5 years. The main group consisted of 90 patients with climacteric syndrome. According to the severity of somatic-vegetative symptoms on a scale MRS patients were divided into three groups: the first (0-5 points); the second (6-8 points) and third (≥ 9 points). The control group consisted of 30 women with hypertension in postmenopausal women with no signs of menopausal syndrome.

It was determined that a significant decrease in enddiastolic volum and left ventricular (LV) ejection fraction, improving endsystolic volum of LV signs of LV hypertrophy in the second and third groups, reduction of peak amplitude E and the increase of the amplitude of the peak A in the group with more severe menopause. Formation of diastolic dysfunction in patients with severe menopause confirmed lower early diastolic velocity of the mitral annulus with the ratio E / EA, indicators IVRT and DT.

In the study of myocardial relaxation type disorders in patients of the first group and the control group was observed predominantly normal left ventricular diastolic relaxation and impaired relaxation. Patients of the second and third groups dominated impaired relaxation and pseudonormal type among patients of the third group met patients with diastolic dysfunction of restrictive type.

Thus, women with hypertension in early postmenopausal found an association with the severity of diastolic dysfunction severity of menopausal symptoms; the most prominent of diastolic relaxation of the left ventricle was observed in the groups with severe and moderate severity of menopausal symptoms; the main type of the observed diastolic dysfunction - impaired relaxation, but in some cases there is pseudonormal and restrictive types.

Keywords: essential arterial hypertension, left ventricle diastolic dysfunction, climacteric syndrome, transmitral blood flow. left ventricle hypertrophy.

This email address is being protected from spambots. You need JavaScript enabled to view it.

The full text

To view the full text

References

  1. Zhao Z., Wang H., Jessup J.A. et al. Role of estrogen in diastolic dysfunction. Am J Physiol Heart Circ Physiol. 2014;306(5):H628-640.
  2. Palmiero P., Maiello M., Daly D.D. et al. Relationship between global pulse wave velocity and diastolic dysfunction in postmenopausal women. Int J Clin Exp Med. 2014;7(12): 5629-5635.
  3. Routledge F.S., Hinderliter A.L., McFetridge-Durdle J. et al. Endothelial function in postmenopausal women with nighttime systolic hypertension. Menopause. 2015; doi: 10.1097/GME.0000000000000405.
  4. Zambrana R.E., López L., Dinwiddie G.Y. et al. Prevalence and incident prehypertension and hypertension in postmenopausal Hispanic women: results from the Women's Health Initiative. Am J Hypertens. 2014; 27(3):372-281.
  5. Albu A., Fodor D., Bondor C., Poantă L. Arterial stiffness, carotid atherosclerosis and left ventricular diastolic dysfunction in postmenopausal women. Eur J Intern Med. 2013; 24(3):250-254.
  6. Wierzbowska-Drabik K., Krzemińska-Pakuła M., Kurpesa M. et al. Impact of gender on left ventricle function in postmenopausal women and age-matched men: analysis of echocardiographic parameters in healthy participants and patients with coronary artery disease. Menopause. 2010;17(3):560-565.
  7. Duygu H., Akman L., Ozerkan F. et al. Comparison of the effects of new and conventional hormone replacement therapies on left ventricular diastolic function in healthy postmenopausal women: a Doppler and ultrasonic backscatter study. Int J Cardiovasc Imaging. 2009;25(4):387-396.
  8. Düzenli M.A., Ozdemir K., Sokmen A. et al. Effects of menopause on the myocardial velocities and myocardial performance index. Circ J. 2007;71(11):1728-1733.