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PLASMA CONCENTRATIONS OF ENDOTHELIN-1 IN YOUNG WOMEN WITH POLYCYSTIC OVARY SYNDROME

AuthorsT. L. Arkhypkina, L. P. Lyubimovа, O. V. Tyazhelova, N. A. Kravchun

Pages: 161–168

Abstract

Polycystic ovary syndrome (РCOS) is one of the most studied pathologies in gynecology, and despite this, its etiology and pathogenesis is not completely understood. Lately, more attention has been paid to study the role of endothelial dysfunction as one of the causes of PCOS.

Objective. Estimate the level of endothelin-1 (as a marker of endothelial dysfunction) in the blood and its relationship with hormonal and metabolic parameters at young women with PCOS.

Methods. We examined 40 patients (age 21.4 ± 0.2 years) with PCOS. All patients have different complaint: for primary infertility – 100%, for menstrual dysfunction in the form of oligomenorrhea – 30 (75%), secondary amenorrhea – 7 (17.5%), hirsutism – 32 (85%), acne – 16 (40%), adiposity – 15 (37.5%). The control group: 15 healthy women with a normal menstrual function, who want to determine the state of the reproductive system before planning of pregnancy.

Results. During the study of the marker of activity endothelial function, there was found that the basal levels of ET-1 in the serum of young women with PCOS (2.29  ±  0,2 fmol/ml) were significantly higher than of the healthy women (0,83 ± 0,2 fmol/ml; p > 0.05). To the frequency of determine of increase ET-1 found that 21 (84%) patients of the first group value of ET-1 in 1.5 times, and in 12 (80%) patients in the second group 2.8 times higher than the healthy women.

Conclusions. It was found that patients with PCOS have increased level of endothelin-1 regardless of body weight and presence or absence metabolic disorders. A positive correlation between levels of endothelin-1 and LH, T/E2 coefficient and a negative correlation with level of E2 was established. Determination of plasma concentrations of endothelin-1 may be useful to identify factors activating endothelial system, but its increase cannot be considered as an independent diagnostic marker for PCOS.

Keywords: polycystic ovary syndrome, metabolic syndrome, endothelin-1.

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