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Аuthors: V. V. Minukhin, N. I. Kovalenko, T. M. Zamazii, I. V. Novikova, G. P. Taranenko

Pages: 374–381



Actuality: There is a change of the general range of infectious agents and their sensitivity to antibiotics. Besides increasing role of opportunistic fungi most of all fungi of the genus Candida in the pathogenesis of infectious diseases of ENT organs is found, and increasing number of strains of the genus Candida fungi resistant to many antifungal preparations is noted.

Objective: studying of the species composition of microflora in ENT pathology and determination of its susceptibility to antimicrobial agents.

Materials and methods: Bacteriological research of various clinical materials from 347 patients with infectious diseases of ENT organs is conducted. Microbiological examination included an isolation of pathogens, identification by morphological, cultural and biochemical properties, determination of the sensitivity of microflora to antibiotics by a diffusion method in agar (the method of standard discs).

Results and discussion: The study found that the leading role in the etiology of infectious disorders of the ear, nose, throat belonged to streptococci of viridans group, S. aureus, S. epidermidis, S. anhemolyticus and fungi Candida species. The greatest sensitivity of all isolated strains was shown to cephoperazone and ciprofloxacin. Tigecycline, ceftriaxone, cephepime and meronem revealed high activity against all bacteria except E. faecalis. Proportion of Candida species was 22.9 %, and 85.8 % of the strains isolated from the nasopharynx, and 81.8 % of the strains isolated from the external ear have been presented in association with the bacteria. 82.5–98.4 % strains were resistant to azoles and amphotericin. Isolated strains of fungi have shown the greatest sensitivity to nystatin.

Conclusions: The obtained data confirmed the requirement to determine the most significant pathogenic flora, which causes diseases of the ENT organs and the respiratory tract organs, its sensitivity to antibiotics, monitoring of resistance at the level of the individual patient, as well as at the regional and country level.

Keywords: microflora of upper respiratory tract, sensitivity to antibiotics, upper respiratory tract infections.

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