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CONTENT AND BALANCE OF TRACE ELEMENTS IN PLACENTA IN PHYSIOLOGICAL PREGNANCY

Аuthors: I. I. Shkolna, V. E. Markevich, H. F. Tkach, O. V. Hordiienko

Pages: 361–366

Abstract

         

Placenta has a number of features that ensure the passage of many biological substances to the fetus as well as the function of barrier for certain substances. According to researchers, it can be used as a marker of unfavorable environmental action.
The aim of study: To identify regulatory indicators of content of essential trace elements (Fe, Cu, Co, Zn, Mg, Mn) in placenta of women which born healthy full term neonates. We also obtained ratios between the essential trace elements that can be used as a normative. We investi-gated the correlation between these microelements in placenta during physiological pregnancy on 37–41 week of gestation.
We have studied the contents of essential trace elements (Fe, Cu, Co, Zn, Mg, Mn) in placenta of women with physiological course of pregnancy.
For the determination of trace elements in placenta used atomic absorption spectrophotometer C-115 M1, equipped with a computer console to automatically calculate the microelements content producing by JSC «Selmi» (Ukraine).
We investigated the concentrations of trace elements in placenta (Fe = 79,91 ± 8,94 mg/g, Cu = 0,83 ± 0,04 mg/g, Co = 0,55 ± 0,2 mg/g, Zn = 45 ± 6,89 mg/g, Mg = 12,22 ± 0,92 mg/g, Mn = 0,73 ± 0,05 mg/g) and proposed the ratio of essential trace elements for using in practice (Fe/Cu=98,84 ± 12,84, Fe/Co = 6185,11 ± 3709,65, Fe/Zn = 2,11 ± 0,38, Fe/Mg = 7,12 ± 1,04, Fe/Mn = 113,25 ± 13,97, Cu/Co = 51,28 ± 27,83, Cu/Zn = 0,024 ± 0,004, Cu/Mg = 0,07 ± 0,007, Cu/Mn = 1,18 ± 0,09, Co/Zn = 0,02 ± 0,01, Co/Mg = 0,04 ± 0,016, Co/Mn = 0,68 ± 0,25, Zn/Mg = 4,11 ± 0,797, Zn/Mn = 64,46 ± 10,51, Mg/Mn = 17,3 ± 1,72). It was noted that a moderate positive correlation between the content of copper and zinc in placenta existed.
Positive correlation of medium strength of content of copper and zinc in placenta was observed. We investigated indicators of content and balance of essential trace elements in placenta of women which born healthy full term neonates. These results should be used as normative
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Keywords: trace elements, placenta, fetus.

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References

  1. Gude NM, Roberts CT, Kalionis B, King RG. [Growth and function of the normal human placenta]. Thromb. Res. 2004; 114(5–6):397–407.
  2. Desforges M, Sibley CP. [Placental nutrient supply and fetal growth]. Int. J. Dev. Biol. 2010; 54(2–3):377–390.
  3. Iyengar GV, Rapp A. [Human placenta as a ‘dual’ biomarker for monitoring fetal and maternal environment with special reference to potentially toxic trace elements. Part 3. Toxic trace elements in placenta and placenta as a biomarker for these elements]. Science of The Total Environment. 2001; 280: 221–238.
  4. Osman K, Akesson A, Berglund M, Bremme K, Schutz A, Ask K, Vahter M. [Toxic and essential elements in placentas of Swedish women]. Clin. Biochem. 2000; 33(2):131–138.
  5. Stawarz R, Formcki G, Chrobaczynska M, Czajkowska M, Chryc K, Kuczkowska-Kuzniar A, Massanyi P, Skalba P. [Accumulation of cadmium and lead in placenta and amnion of women from upper Silesian region, Poland]. Environ. Res. Dev. 2011; 5(4):871–879.
  6. Amaya E, Gil F, Freire C, Olmedo P, Fernandez-Rodrıguez M, Fernandez MF, Olea N. [Placental concentrations of heavy metals in a motherchild cohort]. Environ. Res. 2013;120:63–70.
  7. Zadrożna M, Nowak B, Żołnierek M, Zamorska L, Niweliński J. Human Placenta as a Biomarker of Environmental Toxins Exposure – Long-Term Morphochemical Monitoring, Recent Advances in Research on the Human Placenta. InTech, 2012. pp.19–52. doi: 10.5772/32918
  8. Esteban M, Castaño A. [Noninvasive matrices in human biomonitoring: A review]. Environ. Int. 2009; 35(2):438–449.
  9. Smolders R, Schramm KW, Nickmilder M, Schoeters G. [Applicability of non-invasively collected matrices for human biomonitoring]. Environmental Health. 2009;8:8–18.
  10. Collard KJ. [Iron homeostasis in the neonate]. Pediatrics. 2009;123:1208–1216.
  11. Balesaria S, Hanif R, Salama MF, Raja K, Bayele HK, McArdle H, Srai SK. [Fetal iron levels are regulated by maternal and fetal Hfe genotype and dietary iron]. Haematologica. 2012;97(5):661–670.
  12. Izquierdo Alvarez S, Castanon SG, Ruata ML, Aragues EF, Terraz PB, Irazabal YG, Gonzalez EG, Rodriguez BG. [Updating of normal levels of copper, zinc and selenium in serum of pregnant women]. Journal of Trace Elements in Medicine and Biology. 2007; 21 Suppl 1:49–52.
  13. Zeyrek DSoran MCakmak AKocyigit AIscan A. [Serum copper and zinc levels in mothers and cord blood of their newborn infants with neural tube defects: a case-control study]. Indian Pediatr. 2009;46(8):675–680.
  14. Gambling L, Dunford S, Wallace DI, Zuur G, Solanky N, Srai SK, McArdle HJ. [Iron deficiency during pregnancy affects postnatal blood pressure in the rat]. J Physiol. 2003;552(Pt 2):603–610.
  15. Marquardt MLDone SLSandrock MBerdon WEFeldman KW. [Copper deficiency presenting as metabolic bone disease in extremely low birth weight shot–gut infants]. Pediatrics. 2012;130(3):e695–698.
  16. Legostaeva GA, Zaksas NP, Gluhcheva YG, Sedykh SE, Madzharova ME, Atanassova NN, Buneva VN, Nevinsky GA. [Effect of CoCl2 on the content of different metals and a relative activity of DNA-hydrolyzing abzymes in the blood plasma of mice]. J. Mol. Recognit. 2013;26:10–22.
  17. Vasudevan H, McNeill JH. [Chronic cobalt treatment decreases hyperglycemia in streptozin-diabetic rats]. 2007;20(2):129–134. 
  18. Islam MN, Chowdhury AK, Siddika M, Hossain MA, Hossain MK. [Effect of zinc on growth of preterm babies]. Mymensingh Med J. 2009;18(1):125–130.
  19. Khadem N, Mohammadzadeh A, Farhat ASValaee LKhajedaluee MParizadeh SM. [Relationship between low birth weight neonate and maternal serum zinc concentration]. Iran Red Crescent Med J. 2012;14(4):240–244.
  20. Wulf K, Wilhelm A, Spielmann M, Wirth S, Jenke AC. [Frequency of Symptomatic Zinc Deficiency in very Low Birth Weight Infants]. Klin Padiatr. 2013;225(1):13–17.
  21. Upadhyaya C, Mishra S, Ajmera P, Sharma P. [Serum iron, and zinc status in Maternal and cord blood]. Indian J Clin Biochem. 2004;19(2): 48–52.
  22. Ohata YOzono KMichigami T. [Current concepts in perinatal mineral metabolism]. Clin Pediatr Endocrinol. 2016;25(1):9–17.
  23. Aschner M, Guilarte TR, Schneider JSZheng W. [Manganese: recent advances in understanding its transport and neurotoxicity]. Toxicol Appl Pharmacol. 2007;221(2):131–147.
  24. Erikson KM, Thompson K, Aschner J, Aschner M. [Manganese neurotoxicity: a focus on the neonate]. Pharmacol Ther. 2007;113(2):369–377.
  25. Yoon M, Schroeter JD, Nong A, Taylor MD, Dorman DC, Andersen ME, Clewell HJ 3rd. [Physiologically based pharmacokinetic modeling of fetal and neonatal manganese exposure in humans: describing manganese homeostasis during development]. Toxicol Sci. 2011;122(2):297–316.
  26. Tholin K, Sandström B, Palm R, Hallmans G. [Changes in blood manganese levels during pregnancy in iron supplemented and non supplemented women]. J Trace Elem Med Biol. 1995;9(1):13–17.
  27. Zaitsev IV, Zaitseva OE. [Uroven' soderzhaniya tyazhelykh metallov v platsente zhenshchin i pupovine novorozhdennykh astrakhanskoy oblasti]. Vestnik of astrakhan state technical university. 2004;2(21):172–17.
  28. Markevich VE, Turova LO, Tarasova IV, Markevich VV. [Znachennya defіtsitu ta disbalansu mіkroelementіv u sistemі mati-platsenta-plіd u razі zatrimki vnutrіshn'outrobnogo rozvitku ploda]. Pedіatrіya, Akusherstvo ta Gіnekologіya. 2009;6:12–15.
  29. Mbofung CMF, Subbarau VV. [Trace elements (Zinc, copper, iron and magnesium) concentrations in human placenta and their relationship to birth weight of babies]. Nutrition Research. 1990;10(4):359–366.
  30. Sakamoto M, Yasutake A, Domingo JL, Chan HM, Kubota M, Murata K. [Relationships between trace element concentrations in chorionic tissue of placenta and umbilical cord tissue: Potential use as indicators for prenatal exposure]. Environment International. 2013;60:106–111.
  31. Radomanski T, Sikorski R. [Human placenta magnesium and the contamination with cadmium and lead of placenta]. J Perinat Med.1992;20:181.

I. I. Shkolna,

V. E. Markevich,

H. F. Tkach,

O. V. Hordiienko