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Аuthors: I. I. Shkolna, V. E. Markevich, H. F. Tkach, O. V. Hordiienko

Pages: 361–366



Placenta has a number of features that ensure the passage of many biological substances to the fetus as well as the function of barrier for certain substances. According to researchers, it can be used as a marker of unfavorable environmental action.
The aim of study: To identify regulatory indicators of content of essential trace elements (Fe, Cu, Co, Zn, Mg, Mn) in placenta of women which born healthy full term neonates. We also obtained ratios between the essential trace elements that can be used as a normative. We investi-gated the correlation between these microelements in placenta during physiological pregnancy on 37–41 week of gestation.
We have studied the contents of essential trace elements (Fe, Cu, Co, Zn, Mg, Mn) in placenta of women with physiological course of pregnancy.
For the determination of trace elements in placenta used atomic absorption spectrophotometer C-115 M1, equipped with a computer console to automatically calculate the microelements content producing by JSC «Selmi» (Ukraine).
We investigated the concentrations of trace elements in placenta (Fe = 79,91 ± 8,94 mg/g, Cu = 0,83 ± 0,04 mg/g, Co = 0,55 ± 0,2 mg/g, Zn = 45 ± 6,89 mg/g, Mg = 12,22 ± 0,92 mg/g, Mn = 0,73 ± 0,05 mg/g) and proposed the ratio of essential trace elements for using in practice (Fe/Cu=98,84 ± 12,84, Fe/Co = 6185,11 ± 3709,65, Fe/Zn = 2,11 ± 0,38, Fe/Mg = 7,12 ± 1,04, Fe/Mn = 113,25 ± 13,97, Cu/Co = 51,28 ± 27,83, Cu/Zn = 0,024 ± 0,004, Cu/Mg = 0,07 ± 0,007, Cu/Mn = 1,18 ± 0,09, Co/Zn = 0,02 ± 0,01, Co/Mg = 0,04 ± 0,016, Co/Mn = 0,68 ± 0,25, Zn/Mg = 4,11 ± 0,797, Zn/Mn = 64,46 ± 10,51, Mg/Mn = 17,3 ± 1,72). It was noted that a moderate positive correlation between the content of copper and zinc in placenta existed.
Positive correlation of medium strength of content of copper and zinc in placenta was observed. We investigated indicators of content and balance of essential trace elements in placenta of women which born healthy full term neonates. These results should be used as normative

Keywords: trace elements, placenta, fetus.

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I. I. Shkolna,

V. E. Markevich,

H. F. Tkach,

O. V. Hordiienko