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CHARACTERISTICS OF ARTERIAL STIFFNESS IN PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE ALONG WITH CHRONIC HEART FAILURE

Аuthors: L. B. Vynnychenko, A. O. Pryvalova

Pages: 779–785

Abstract

         

The aim of study was to assess indicators of vascular stiffness in patients with chronic obstructive pulmonary disease (COPD) along with chronic heart failure (CHF). The total number of patients under study was 94. They were matched by age and sex in all study groups. Patients with COPD have made up the 1st study group (n = 56). The 2nd group consisted of patients with COPD along with the CHF (n = 20). The control group consisted of male smokers with no evidence of COPD and CHF (n = 18). Applanation tonometry with contour analysis of pulse wave was made for measuring the central aortic pressure and carotid-femoral pulse wave velocity (PWV) using the SphygmoCor device (AtCor Medical, Australia). The following parameters were assessed: systolic, diastolic, pulse pressure in the aorta, augmentation pressure in the aorta, PWV. Investigation results showed that COPD patients have stable significant increase of central arteries stiffness that is evident as increase of PWV in the aorta (9.7 ± 0.9 m/s and 6.3 ± 0.6 m/s correspondingly) and increase of pressure augmentation (9.1 ± 0.05 mmHg and 6.1 ± 0.9 mm Hg, correspondingly) compared with patients in the control group. The increase of arterial stiffness grows synchronously with the severity of disease. There was found significant more increased PWV in patients with COPD along with CHF compared with those without CHF and it was 12.8 ± 0.7 m/s and 9.7 ± 0.9 m/s correspondingly. In both study groups there has been observed significant increase of PWV in patients with body weight index (BWI) < 24.9 kg/m2 compared to those who have BWI > 25 kg/m2.

Keywords: chronic obstructive pulmonary disease, chronic heart failure, arterial stiffness, pulse wave velocity, augmentation pressure.

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