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GLUCOSE METABOLISM CHARACTERISTICS AND THE I/D GENE POLYMORPHISM OF THE ANGIOTENSIN-CONVERTING ENZYME IN HE PATIENTS WITH ARTERIAL HYPERTENSION ACCOMPANYING WITH A TYPE II DIABETES MELLITUS

Authors: Kulikova M. V., Ascheulova T. V.

Pages: 256-261

 

Abstract

        The article is devoted to study carbohydrate metabolism characteristics and identify the I/D gene polymorphism of the angiotensin-converting enzyme in the patients with arterial hypertension. This arterial hypertension is accompanied with a type II diabetes mellitus. We examined 103 patients with arterial hypertension; they were randomized into two groups distinguishing either they preserve or not the type II diabetes mellitus. During the research we have figured out that the majority of patients from the both groups were the carriers of D-allele angiotensin-converting enzyme gene (the patients with DD and ID genotypes). The patients with arterial hypertension and unfavorable DD and ID genotypes had significant worsening of carbohydrate metabolism characteristics, such as insulin and HbA1c. It can be regarded as the proof of a bad prognosis about possible the type II diabetes mellitus development if the D-allele angiotensin-converting enzyme gene is carried. Existence of ID genotype caused body-weight and arterial pressure increasing. We have pointed out essential differences among systolic pressure, diastolic pressure, body-weight index and insulin in the patients from the 2nd group (the subgroup with a manifestation of ID genotype). These proved the complicated character of arterial hypertension course, which was accompanied with the type II diabetes mellitus.

Key words: carbohydrate metabolism, gene polymorphism, arterial hypertension, type II diabetes mellitus, genotype.

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