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Bcl1 POLYMORPHISMS OF GLUCOCORTICOID RECEPTOR GENE ASSOCIATIONS WITH ANTHROPOMETRIC AND METABOLIC CRITERIA

Authors: Prystupa L.N., Kmyta V. V., Savchenko O. V.

Pages: 121 - 130

 

Abstract

        

            The article analyzes the research results concerning prevalence of one of the most wide-spread glucocorticoid receptor (GR) gene polymorphisms Bcl1 (rs 41423247) in different populations. Its role in increasing sensitivity to glucocorticoids (GCC) is proved here. The article provides the analysis of Bcl1 polymorphism associations with body mass index, abdominal obesity and fat centralization index as well as with metabolic criteria – blood glucose and insulin level, HOMA index, lipid profile. In spite of contradictory information from the literature sources, Bcl1 polymorphism can serve as a predictor of obesity and metabolic syndrome. Whereas associating polymorphism to the above-mentioned criteria, depends on ecological, alimentary and socioeconomic factors, population inhomogeneity, generation differences and interactions with other gene polymorphisms. Therefore, Bcl1 polymorphism of the GR gene is associated with the change of sensitivity to GCC and phenotypic characters. It can also be partially responsible for genetic determination of body constitution and metabolic state.
        Key words: glucocorticoid receptor gene, Bcl1 polymorphism, body mass index, metabolic parameters, sensitivity to glucocorticoids

 

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