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THE DIAGNOSTIC VALUE OF MARKERS OF THE CENTRAL NERVOUS SYSTEM AND KIDNEY INJURY IN NEONATES UNDERGOING ASPHYXIA

Authors: Loboda A.M. , Markevich V.E.

Pages: 64-71

Abstract

      

The article is devoted to the study a diagnostic value of early markers of CNS (neuron specific enolase (NSE)) and kidney injury (cystatin C) in neonates undergoing asphyxia.

The study involved 75 full-term neonates with kidney disturbance: 45 children undergone severe asphyxia, and 30 children with moderate asphyxia. Comparison group consisted of 20 healthy children. Serum concentration of NSE and cystatin C measured on 1–2nd, 7–8th and 25–30th days of life by ELISA.

A significant level of NSE (above 29.5 ng/ml) is the early confirmation of the diagnosis of asphyxia. NSE content, which is above 56.2 ng/ml (1–2th days of life), is critical to predict the renal dysfunction development.

Increased cystatin C level after birth is an early and universal feature of hypoxic damage of the kidneys, as its serum level increases rapidly and reliably even at moderate asphyxia. The degree of kidney damage, depending on the severity of the asphyxia can be determined by the serum cystatin C level from the end of the early neonatal period. Detection of high concentrations of neurospecific proteins in serum at the late neonatal period requires monitoring of serum cystatin C.

Key words: asphyxia, neuron specific enolase, cystatin C, kidney, newborn.

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