Get Adobe Flash player

СВЯЗЬ K121Q-ПОЛИМОРФИЗМА ГЕНА ЕКТОНУКЛЕОТИД ПИРОФОСФАТАЗА/ФОСФОДИЭСТЕРАЗА 1 (ENPPI) С ОСТРЫМ КОРОНАРНЫМ СИНДРОМОМ У ЛИЦ РАЗНОГО ПОЛА

Автор: Розуменко И. А. 

Страницы: s38-s44

Аннотация

   

Приведены результаты изучения K121Q-полиморфизма гена ENPPI в 118 пациентов с острым коронарным синдромом (ОКС) и 110 здоровых индивидуумов (контрольная группа) разного пола. Установлено, что нет связи между полом пациентов и развитием ОКС в зависимости от генотипа по К121Q-полиморфизму гена ЕNРР1.

Ключевые слова: ектонуклеотид пирофосфатаза/ фосфодиэстераза 1, острый коронарный синдром, полиморфизм генов.

inchik-27486@yandex.ru

 

Список литературы

  1. Johnson K, Goding J, Van Etten D, Sali A, Hu SI, Farley D, Krug H, et alLinked deficiencies in extracellular PP(i) and osteopontin mediate pathologic calcification associated with defective PC-1 and ANK expression. J Bone Miner Res.2003;18(6):994–1004.
  2. Ruf N, Uhlenberg B, Terkeltaub R, NurnbergP, Rutsch F. The mutational spectrum of ENPP1 as arising after the analysis of 23 unrelated patients with Generalized Arterial Calcification of Infancy (GACI). Human Mutation. 2005;26(5):495–496.
  3. Rutsch F, Vaingankar S, Johnson K, GoldfineI, Maddux B, Schauerte P, KalhoffH, et alPC-1 nucleoside triphosphate pyrophosphohydrolase deficiency in idiopathic infantile arterial сalcification. American Journal of Pathology. 2001;158(2):543–554.
  4. Glatz AC, Pawel BR, Hsu DT, Weinberg P, Chrisant MRK. Idiopathic infantile arterial calcification: two case reports, a review of the literature and a role for cardiac transplantation. Pediat Transplant. 2006; 10:225–233.
  5. Nakamura I, Ikegawa S, Okawa A, Okuda S, Koshizuka Y, Kawaguchi H, Nakamura K, et alAssociation of the human NPPS gene with ossification of the posterior longitudinal ligament of the spine (OPLL). Hum Genet. 1999;104(6):492–497.
  6. Pizzuti A, Frittitta L, Argiolas A, Baratta R,. Goldfine ID, Bozzali M, Ercolino T, et alA p Diabetеs. 1999; 48(9):1881–1884.
  7. Bacci S, Ludovico O, Prudente S, Zhang Y-Y, Di Paola R, Mangiacotti D, Rauseo A, et alThe K121Q polymorphism of the ENPP1/PC-1 gene is associated with insulin resistance/atherogenic phenotypes, including earlier оnset of type 2 diabetes and myocardial infarction. Diabetеs. 2005; 54(10):3021–3025.
  8. Meyre D, Bouatia-Naji N, Vatin V, Veslot J, Samson C, Tichet J, Marre M, et alENPP1 K121Q polymorphism and obesity, hyperglycaemia and type 2 diabetes in the prospective DESIR Study. Diabetologia. 2007;50:2090–2096.
  9. El Achhab Y, Meyre D, Bouatia-Naji N, Berraho M, Deweirder M, Vatin V, Delplanque J, et alAssociation of the ENPP1 K121Q polymorphism with type 2 diabetes and obesity in the Moroccan population. Diabetes Metab. 2009;35(1):37–42.
  10. Lee JE, Choi YK, Seo HA, Jeon JH, Jeong JY, Moon SS, Kim JG, et alImpact of ENPP1 and MMP3 gene polymorphisms on aortic calcification in patients with type 2 diabetes in a Korean population.Diabetes Res Clin Pract. 2010;88(1):87–96.
  11. Cte N, El Husseini D, Pepin A, Guauque-Olarte S, Ducharme V, Bouchard-Cannon P, Audet A, Fournier D, et al.ATP acts as a survival signal and prevents the mineralization of aortic valve. J Mol Cell Cardiol. 2012;52(5):1191–202.
  12. Moehlecke M, Kramer KC, Cristiane B, KraheAL, Balbosco I, de Azevedo JM, Gross JL, Canani LH. ENPP1 K121Q polymorphism and ischemic heart disease in diabetic patients. Arq Bras Cardiol. 2010;94(2):157–161.
  13. Eller P, Schgoer W, Mueller T, Tancevski I, Demetz E, Duwensee K, Ritsch A, et alThe K121Q polymorphism of ENPP1 and peripheral arterial disease. Heart Vessels. 2008;23(2):104–107.
  14. Wang RQ, Zhou DH, Xi B, Ge XS, Zhu P, Wang B, Zhou MA, etalENPP1/PC-1 gene K121Q рolymorphism іs аssociated with оbesity in European аdult p Biomed Environ Sci. 2011;24(2):200–206.
  15. Gonzalez-Sanchez JL, Zabena C, Martinez-Larrad MT, Martinez-Calatrava MJ, Perez-Barba M, Serrano-Ríos M. Association of ENPP1 (PC-1) K121Q polymorphism with obesity-related parameters in subjects with metabolic syndrome. Clin Endocrinol. 2008;68(5):724
  16. Suk EK, Malkin I, Dahm S, Kalichman L, RufN, Kobyliansky E, Toliat M, et alAssociation of ENPP1 gene polymorphisms with hand osteoarthritis in a Chuvasha population. Arthritis Res Ther. 2005;7(5): R1082–1090.
  17. Baba T, Endo T, Sata F, Honnma H, KitajimaY, Hayashi T, Manase K, et alPolycystic ovary syndrome is associated with genetic polymorphism in the insulin signaling gene IRS-1 but not ENPP1 in a Japanese population. Life Sci. 2007;81(10):850–854.
  18. Takahama Y, Uto H, Kanmura S, Oketani M, Ido A, Kusumoto K, Hasuike S, et alAssociation of a genetic polymorphism in ectonucleotide pyrophosphatase/phosphodiesterase 1 with hepatitis C virus infection and hepatitis C virus core antigen levels in subjects in a hyperendemic area of Japan. J Gastroenterol. 2008;43(12):942–950.
  19. Levy-Litan V, Hershkovitz E, Avizov L, Leventhal N, Bercovich D, Chalifa-Caspi V, Manor E, et alAutosomal-recessive hypophosphatemic rickets is associated with an inactivation mutation in the ENPP1 g Am J Hum Genet. 2010;86(2):273–8.
  20. Braunwald E, Antman EM, Beasley JW, Califf RM, Cheitlin MD, Hochman JS, Jones RH, et alACC/AHA guidelinesfor the management of patients with unstable angina and non ST-elevation myocardial infarction: executive summary and recommendations. A report of the american college of cardiology. Circulation. 2000;102:1193–1209.
  21. Bertrand ME, Simoons ML, Fox KA, Wallentin LC, Hamm CW, McFadden E, De Feyter PJ, Specchia G, Ruzyllo W. Management of acute coronary syndromes in patients presenting without persistent ST-segment elevation. Eur Heart J. 2002;23:1809–1840.
  22. Chen MP, Chung FM, Chang DM, Tsai J, Huang HF, Shin SJ, Lee YJ. ENPP1 K121Q Polymorphism is not related to type 2 diabetes mellitus, features of metabolic syndrome, and diabetic cardiovascular complications in a Chinese Population. Rev Diabet Stud. 2006;3(1):2130.

Copyright ,

Журнал клiнiчних та експериментальних медичних дослiджень © 2013. 

All Rights Reserved.