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ДОСЛІДЖЕННЯ АСОЦІАЦІЇ ПОЛІМОРФІЗМУ A1166C ГЕНА AGTR1 З РИЗИКОМ РОЗВИТКУ МОЗКОВОГО ІНСУЛЬТУ В ПОПУЛЯЦІЇ РОСІЙСЬКИХ ЖИТЕЛІВ ЦЕНТРАЛЬНОЇ РОСІЇ

Автор: Бушуева О. Ю., Стецька Т. А., Вялих Є. К., Іванов В. П., Полоніков О. В.

Сторінки: 176-184

Анотація

         

Метою дослідження було вивчення асоціації поліморфізму A1166C гена AGTR1 (rs5186) зі схильністю до мозкового інсульту (МІ) на фоні гіпертонічної хвороби у популяції російських жителів Центрального Чорнозем’я.

Матеріалом дослідження стали 830 зразків ДНК. 454 пацієнти з мозковим інсультом та 278 відносно здорових індивідуумів відповідної статі та віку із нормальним рівнем артеріального тиску. Генотипування поліморфізмів виконували методом алельної дискримінації за допомогою TaqMan-зондів.

При порівняльному аналізі частот алелей і генотипів поліморфізму A1166C гена AGTR1 (як в узагальненому, так і у стратифікованому за статтю аналізі) відмінностей між групами не було відмічено.

Поліморфізм A1166C гена AGTR1 не асоційований з ризиком розвитку мозкового інсульту у російських жителів Центрального Чорнозем’я. 

Ключові словамозковий інсульт, спадкова схильність, гени-кандидати, рецептор до ангіотензину ІІ, ренін-ангіотензин-альдостеронова система, однонуклеотидний поліморфізм. 

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