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КИШКОВИЙ ГОМЕОСТАЗ ТА ВІЛ-ІНФЕКЦІЯ (ОГЛЯД ЛІТЕРАТУРИ)

Автор: Дьяченко А. Г., Горобченко К. М., Савінова О. М., Мірошниченко О. О., Шкрьоба О. А. 

Сторінки: 259-272

Анотація

         

Постійний баланс між мікробіотою, кишковим бар'єром і мукозною імунною системою є основою нормального кишкового гомеостазу. ВІЛ-інфекція призводить до помітних порушень імунного статусу та структурних пошкоджень слизової оболонки кишечнику, що становить загрозу бар'єрній функції. Ослаблення імунного тиску призводить до дисбіотичних процесів і мікробної транслокації, що викликає хронічну активацію імунної системи і прогресування ВІЛ-інфекції. Хоча впровадження комбінованої антиретровірусної терапії є великим досягненням у лікуванні ВІЛ-інфекції, зберігається потреба у деяких додаткових заходах, спрямованих на відновлення структури та функціональної цілісності кишкового епітелію.

Метою огляду є аналіз впливу ВІЛ-інфекції на стан кишкового  мікробіоценозу, а також на гіперактивацію імунної системи,  асоційованої з розвитком захворювання.

Ключові слова: кишкова мікробіота, кишковий бар'єр, дисбактеріоз, ВІЛ-інфекція.

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